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Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations.

Julio Sanjuán·Amparo Tolosa·José C González·Eduardo J Aguilar·Jordi Pérez-Tur·Carmen Nájera·María Dolores Moltó·Rosa de Frutos
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Abstract

OBJECTIVE: A mutation in the FOXP2 gene has been the first genetic association with a language disorder. Language disorder is considered as a core symptom of schizophrenia. Therefore, the FOXP2 gene could be considered a good candidate gene for the vulnerability to schizophrenia. METHODS: A set of single nucleotide polymorphisms mainly located in the 5' regulatory region of the FOXP2 gene was analysed in a sample of 186 DSM-IV schizophrenic patients with auditory hallucinations and in 160 healthy controls. RESULTS: Statistically significant differences in the genotype (P=0.007) and allele frequencies (P=0.0027) between schizophrenic patients with auditory hallucinations and controls were found in the single nucleotide polymorphism rs2396753. These P values changed to 0.07 and 0.0273, respectively, after Bonferroni sequential correction. The haplotype rs7803667T/rs10447760C/rs923875A/rs1358278A/rs2396753A (TCAAA) also showed a significant difference confirmed with a permutation test (P=0.009). CONCLUSIONS: These results suggested that the FOXP2 gene may confer vulnerability to schizophrenic patients with auditory hallucinations.

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AdultAgedAllelesFemaleForkhead Transcription FactorsGene FrequencyGenetic Predisposition to DiseaseGenotypeHallucinationsHumansMaleMiddle AgedPolymorphism, Single NucleotideSchizophreniaSpainWhite PeopleJournal ArticleResearch Support, Non-U.S. Gov't

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Julio Sanjuán, Amparo Tolosa, José C González, Eduardo J Aguilar, Jordi Pérez-Tur, Carmen Nájera, María Dolores Moltó, Rosa de Frutos. 2006. Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations.. https://doi.org/10.1097/01.ypg.0000185029.35558.bb

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