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PubMed · 16539923

[Macroorchidism: a case report].

M Alvarez-Acevedo García·María A Molina Rodríguez·I González Casado·M Nistal Martín de Serrano·R Gracia Bouthelier
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Abstract

Macroorchidism is a rare condition in children and is usually associated with fragile X syndrome. Other possible etiologies of macroorchidism are long-standing primary hypothyroidism, adrenal remnants in congenital adrenal hyperplasia, follicle stimulating hormone (FSH)-secreting pituitary macroadenomas, local tumors, lymphomas, and aromatase deficiency. Bilateral macroorchidism can be a normal variant in adult men. We report the case of an 11.5-year-old boy who was referred to our hospital for evaluation of marked bilateral testicular enlargement in the previous few months. Physical examination revealed a testicular volume larger than 30 ml. Complementary investigations allowed us to rule out all hitherto reported etiologies of bilateral macroorchidism and therefore a diagnosis of idiopathic macroorchidism was established. The increased number of Sertoli cells found on biopsy, without elevated plasma FSH levels, prompted us to speculate about a hypothetical FSH receptor hyperfunction as a possible cause of the exaggerated testicular enlargement in this patient.

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ChildHumansMaleReceptors, FSHSertoli CellsTesticular DiseasesCase ReportsEnglish AbstractJournal Article

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M Alvarez-Acevedo García, María A Molina Rodríguez, I González Casado, M Nistal Martín de Serrano, R Gracia Bouthelier. 2006. [Macroorchidism: a case report].. https://doi.org/10.1016/s1695-4033(06)70015-7

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