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PubMed · 16541724

[Structure and biologic function of IFNgamma].

Abdul Halim Nammous·Małgorzata Pietruczuk·Dymitr Zubacki·Ignacy Dobrzycki
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Abstract

IFNgamma is a pro-inflammatory, pleiotropic cytokine mainly produced by the CD4+, CD8+ lymphocytes and NK cells, that play an important role in macrophage activation, antigen presentation enhance and induce innate, and acquired immune responses. IFNgamma by interaction with they cell-surface receptors (IFNgammaR) activates cellular effects including stimulation of antiviral and antimicrobial mechanisms, inhibition of cellular proliferation, regulates cells apoptosis and leukocyte trafficing to sites of inflammation. The purpose of this article is to present the current understending of structure and biological function of IFNgamma in the light of current opinions regarding this matter.

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CD4 AntigensCD8 AntigensCell ProliferationHumansInterferon-gammaLymphocytesNitric Oxide SynthaseReceptors, Cell SurfaceTumor Necrosis Factor-alphaJournal ArticleReview

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Abdul Halim Nammous, Małgorzata Pietruczuk, Dymitr Zubacki, Ignacy Dobrzycki. 2005. [Structure and biologic function of IFNgamma].. https://pubmed.ncbi.nlm.nih.gov/16541724/

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