Inherited autoinflammatory recurrent fevers.

A Pradalier; A Cauvain; Z Oukachbi

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PubMed · 16544581

Inherited autoinflammatory recurrent fevers.

A Pradalier·A Cauvain·Z Oukachbi

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Abstract

Autoinflammatory diseases have a quite similar clinical picture and are characterised by recurrent episodes of fever, joint features, abdominal features and skin features. Auto-inflammatory syndrome are related to mutations in genes implied in apoptosis or inflammation. FMF's gene is MEFV, present on the short arm of the chromosom 6, encoding the pyrin or marenostrie which is widely expressed in neutrophils and monocyts and implied in the control of the inflammation. Muckle wells syndrome and Familial cold urticaria are related to CIAS1 gene mutations which are located on the long arm of the chromosome 1 and encodes cryopirine involved in apoptosis. TRAPS gene is present on the chromosome 12, the majority of mutations are located in the extra cellular region of the receptor.

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Autoimmune Diseases Carrier Proteins Cytoskeletal Proteins Fever Humans Mutation NLR Family, Pyrin Domain-Containing 3 Protein Pyrin Journal Article Review

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A Pradalier, A Cauvain, Z Oukachbi. 2006. Inherited autoinflammatory recurrent fevers.. https://pubmed.ncbi.nlm.nih.gov/16544581/

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