DNA mimicry by proteins.

D T F Dryden; M R Tock

doi:10.1042/bst20060317

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PubMed · 16545103

DNA mimicry by proteins.

D T F Dryden·M R Tock

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Abstract

It has been discovered recently, via structural and biophysical analyses, that proteins can mimic DNA structures in order to inhibit proteins that would normally bind to DNA. Mimicry of the phosphate backbone of DNA, the hydrogen-bonding properties of the nucleotide bases and the bending and twisting of the DNA double helix are all present in the mimics discovered to date. These mimics target a range of proteins and enzymes such as DNA restriction enzymes, DNA repair enzymes, DNA gyrase and nucleosomal and nucleoid-associated proteins. The unusual properties of these protein DNA mimics may provide a foundation for the design of targeted inhibitors of DNA-binding proteins.

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Animals DNA DNA Restriction Enzymes Enzyme Inhibitors Molecular Mimicry Protein Binding Proteins Journal Article Research Support, Non-U.S. Gov't Review

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D T F Dryden, M R Tock. 2006. DNA mimicry by proteins.. https://doi.org/10.1042/bst20060317

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