Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization.

Etienne Boulter; Ellen Van Obberghen-Schilling

doi:10.1016/j.ejcb.2005.09.002

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Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization.

Etienne Boulter·Ellen Van Obberghen-Schilling

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Abstract

Integrin-linked kinase (ILK) represents a key component of integrin signaling complexes that functions in concert with multiple binding partners to transmit cues from the extracellular matrix environment to the actin cytoskeleton. Both gain- and loss-of-function approaches to study ILK have confirmed the essential role of this protein in regulating cell-matrix adhesion dynamics and cytoskeletal organization.

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Actin Cytoskeleton Animals Cell Adhesion Cell-Matrix Junctions Extracellular Matrix Gene Expression Regulation Humans Models, Biological Models, Genetic Protein Binding Protein Serine-Threonine Kinases Signal Transduction rho GTP-Binding Proteins Scaffold Protein ILK Journal Article Research Support, Non-U.S. Gov't Review

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Etienne Boulter, Ellen Van Obberghen-Schilling. 2005-10-10. Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization.. https://doi.org/10.1016/j.ejcb.2005.09.002

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