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PubMed · 16546741

[Preliminary quantitative study of dynamic magnetic resonance diffusion tensor imaging in rabbit models implanted with hepatic tumor grafts from VX2].

Shao-bin Xu·Xian-yue Quan·Xi-jie Sun
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Abstract

OBJECTIVE: To investigate the feasibility of dynamic magnetic resonance diffusion tensor imaging (DTI) in rabbit models with implanted VX2 hepatic tumor grafts. METHODS: MRI and DTI images were obtained from 16 rabbit models with implanted VX2 hepatic tumor grafts (14, 18, 22, and 26 days after tumor implantation, respectively) and 4 normal rabbits. The average diffusion coefficient (ADC) and exponential ADC (eADC) were estimated and compared against pathological findings. RESULTS: The ADC values increased after tumor implantation but then decreased in the rabbit models, whereas eADC exhibited a pattern of reverse changes. These changes significantly differed from those in the control group. Coagulation necrosis and fibrous hyperplasia showed obvious increase as found by pathological examination. CONCLUSION: Dynamic MR DTI quantitative analysis of rabbit models of implanted VX2 hepatic tumor can partially describe the growth behaviors of implanted liver cancer.

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AnimalsCarcinoma, HepatocellularDiffusion Magnetic Resonance ImagingFemaleImage EnhancementLiver NeoplasmsMaleNeoplasm TransplantationRabbitsRandom AllocationEnglish AbstractJournal ArticleResearch Support, Non-U.S. Gov't

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Shao-bin Xu, Xian-yue Quan, Xi-jie Sun. 2006. [Preliminary quantitative study of dynamic magnetic resonance diffusion tensor imaging in rabbit models implanted with hepatic tumor grafts from VX2].. https://pubmed.ncbi.nlm.nih.gov/16546741/

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