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Preparation of beta-nitroalanine using the Easton three-component coupling method.

K M Soapi·C A Hutton
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Abstract

A simple one-step preparation of beta-nitroalanine has been developed using the Easton three-component coupling method. To date one limitation of this method has been that use of nitromethane as the nitroalkane component does not yield beta-nitroalanine. We report that use of the dipotassium salt of nitroacetic acid in the Easton three-component coupling gives beta-nitroalanine in high yield, presumably via facile decarboxylation of a beta-nitroaspartate intermediate.

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BibTeXRIS

K M Soapi, C A Hutton. 2006-03-20. Preparation of beta-nitroalanine using the Easton three-component coupling method.. https://doi.org/10.1007/s00726-006-0261-x

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