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PubMed · 16549043

Cancer immunotherapy targeting the telomerase reverse transcriptase.

Long Fei Huo·Janice Ws Tang·Jun Jian Huang·Pei Tang Huang·Cui Fen Huang·Hsiang Fu Kung·Marie C Lin
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Abstract

The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen (TAA) to develop potential vaccine specifically destroying cancers without impairing normal tissues in human cancer immunotherapy. Here are reviewed the fundamental advances of studies on immunogenicity of hTERT or its peptides and the early clinical trials using the hTERT vaccine approach in the last decades.

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Antigens, NeoplasmCancer VaccinesClinical Trials as TopicDNA-Binding ProteinsHumansImmunotherapyNeoplasmsPeptidesTelomeraseJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Long Fei Huo, Janice Ws Tang, Jun Jian Huang, Pei Tang Huang, Cui Fen Huang, Hsiang Fu Kung, Marie C Lin. 2006. Cancer immunotherapy targeting the telomerase reverse transcriptase.. https://pubmed.ncbi.nlm.nih.gov/16549043/

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