High voltage activated calcium channels: molecular composition and function.

V Flockerzi; E Bosse; M Biel; R Hullin; F Hofmann

doi:10.1093/eurheartj/12.suppl_d.95

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High voltage activated calcium channels: molecular composition and function.

V Flockerzi·E Bosse·M Biel·R Hullin·F Hofmann

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Abstract

Voltage-activated calcium channels comprise a group of similar yet distinct proteins or protein complexes that differ in electrophysiological properties, modulation by phosphorylation and GTP-binding proteins and in their relative sensitivity to organic calcium channel blockers. Cloning of the cDNA of L-type calcium channels from skeletal muscle, heart and smooth muscle opens the way to understanding the molecular basis of channel function and regulation and provides means of studying calcium channels in other tissues.

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Animals Calcium Channel Blockers Calcium Channels Muscle, Smooth Muscles Myocardium Rabbits Receptors, Nicotinic Journal Article Research Support, Non-U.S. Gov't

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V Flockerzi, E Bosse, M Biel, R Hullin, F Hofmann. 1991. High voltage activated calcium channels: molecular composition and function.. https://doi.org/10.1093/eurheartj%2F12.suppl_d.95

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