Ecallantide (Dyax/Genzyme).

Andreas Lehmann

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PubMed · 16555689

Ecallantide (Dyax/Genzyme).

Andreas Lehmann

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Abstract

Ecallantide is one of a series of small-protein kallikrein inhibitors, identified through Dyax Corp's phage display technology, that is being developed by Dyax and Genzyme as a potential subcutaneous treatment for hereditary angioedema (HAE). Dyax is also independently developing ecallantide for the reduction of peri-operative blood loss during cardiopulmonary bypass surgery. The company had expected to begin phase II clinical studies in coronary bypass graft patients in the first half of 2005; however, by October 2005, these trials had been delayed until partnership negotiations for the program were completed. A pivotal, phase III clinical trial of ecallantide in HAE began in December 2005.

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Analgesics, Non-Narcotic Angioedema Anti-Inflammatory Agents, Non-Steroidal Clinical Trials, Phase III as Topic Humans Kallikreins Peptides Recombinant Proteins Journal Article

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Andreas Lehmann. 2006. Ecallantide (Dyax/Genzyme).. https://pubmed.ncbi.nlm.nih.gov/16555689/

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