PubMed · 16561244
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R E Dolkart, F L Dey, G X Schwemlein. 1947. Penicillin Assay Techniques: A Comparative Study.. https://doi.org/10.1128/jb.53.1.17-24.1947
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The first part of this account of the discovery of penicillin, published in last month's issue of TIBS, concluded with the detection of 6-beta-amino-penicillanic acid (6-APA), the nucleus of the penicillin structure. The exploitation of 6-APA led to the preparation of a range of clinically important semi-synthetic penicillins, which is described in this article.
The synthesis and antibacterial activity of a series of penicillins and 6 alpha-formamidopenicillins containing a C(5) or C(6)-substituted piperazine-2,3-dione moiety in the C(6)-beta-sidechain is described.
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