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Transcriptional repressor Blimp-1 regulates T cell homeostasis and function.

Gislâine A Martins·Luisa Cimmino·Miriam Shapiro-Shelef·Matthias Szabolcs·Alan Herron·Erna Magnusdottir·Kathryn Calame
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Abstract

The B lymphocyte-induced maturation protein 1 (Blimp-1) transcriptional repressor is required for terminal differentiation of B lymphocytes. Here we document a function for Blimp-1 in the T cell lineage. Blimp-1-deficient thymocytes showed decreased survival and Blimp-1-deficient mice had more peripheral effector T cells. Mice lacking Blimp-1 developed severe colitis as early as 6 weeks of age, and Blimp-1-deficient regulatory T cells were defective in blocking the development of colitis. Blimp-1 mRNA expression increased substantially in response to T cell receptor stimulation. Compared with wild-type CD4(+) T cells, Blimp-1-deficient CD4(+) T cells proliferated more and produced excess interleukin 2 and interferon-gamma but reduced interleukin 10 after T cell receptor stimulation. These results emphasize a crucial function for Blimp-1 in controlling T cell homeostasis and activation.

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AnimalsCD4-Positive T-LymphocytesCell DifferentiationColitisCytokinesDNA-Binding ProteinsDown-RegulationHomeostasisMicePlasma CellsPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-bcl-6Repressor ProteinsT-Lymphocyte SubsetsThymus GlandTranscription FactorsTranscription, GeneticJournal ArticleResearch Support, N.I.H., Extramural

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Gislâine A Martins, Luisa Cimmino, Miriam Shapiro-Shelef, Matthias Szabolcs, Alan Herron, Erna Magnusdottir, Kathryn Calame. 2006-03-26. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function.. https://doi.org/10.1038/ni1320

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