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Longitudinal changes during aging using proton magnetic resonance spectroscopy.

Amy J Ross·Perminder S Sachdev·Wei Wen·Henry Brodaty
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Abstract

OBJECTIVE: We aimed to examine the longitudinal change in proton magnetic resonance spectroscopy ((1)H-MRS) visible metabolites (N-acetyl aspartate [NAA], creatine [Cr], choline [Cho], and myo-Inositol [mI]) in brains of elderly individuals over 3 years and relate them to cognitive function. METHODS: Neurologically and psychiatrically normal volunteers (n = 40) were examined at baseline and 3 years later with (1)H-MRS in two voxels (frontal white matter n = 29, and occipitoparietal gray matter n = 36) and with detailed neuropsychological assessments. Longitudinal analyses were performed with age, educational level, sex, and white matter hyperintensities (WMH) in voxels as covariates. RESULTS: Frontal mI was significantly increased over time in male participants, but all other metabolites were stable over time. Neuropsychological performance was not significantly changed over 3 years, and there was no relationship between change in metabolite levels and change in neuropsychological function. CONCLUSIONS: MRS-visible metabolites are stable in elderly persons over 3 years, with the exception of mI which shows an increase. Increasing mI may be a marker of aging or a preclinical neurodegenerative process. MRS changes do not correlate with change in neurocognitive function during aging.

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AgedAged, 80 and overAgingAnalysis of VarianceAspartic AcidBrainChi-Square DistributionCholineCreatineFemaleHumansInositolMagnetic Resonance SpectroscopyMaleMiddle AgedNeuropsychological TestsProtonsTime FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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Amy J Ross, Perminder S Sachdev, Wei Wen, Henry Brodaty. 2006. Longitudinal changes during aging using proton magnetic resonance spectroscopy.. https://doi.org/10.1093/gerona%2F61.3.291

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