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PubMed · 16571837

Cellular factors required for Lassa virus budding.

Shuzo Urata·Takeshi Noda·Yoshihiro Kawaoka·Hideyoshi Yokosawa·Jiro Yasuda
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Abstract

It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.

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ATPases Associated with Diverse Cellular ActivitiesAdenosine TriphosphatasesAnimalsCOS CellsChlorocebus aethiopsDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportLassa virusNedd4 Ubiquitin Protein LigasesRNA, Small InterferingRepressor ProteinsTranscription FactorsTransfectionUbiquitin-Protein LigasesVacuolar Proton-Translocating ATPasesVesicular Transport ProteinsVirionTsg101 ProteinJournal ArticleResearch Support, Non-U.S. Gov't

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Shuzo Urata, Takeshi Noda, Yoshihiro Kawaoka, Hideyoshi Yokosawa, Jiro Yasuda. 2006. Cellular factors required for Lassa virus budding.. https://doi.org/10.1128/jvi.80.8.4191-4195.2006

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