Teaching molecular genetics: Chapter 3--Proteomics in nephrology.

Patricia J T A Groenen; Lambert P W J van den Heuvel

doi:10.1007/s00467-006-0064-z

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Teaching molecular genetics: Chapter 3--Proteomics in nephrology.

Patricia J T A Groenen·Lambert P W J van den Heuvel

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Abstract

The novel discipline of proteomics has experienced a rapid growth in the recent past and has great potentials for the future. The study of proteins on a genomic scale enables a large number of proteins to be analysed simultaneously. Moreover, proteomic analysis reveals the presence of protein isoforms and post-translational modifications, both of which have the potential to regulate protein complex formation, activity and function. As such, the assessment of the proteome, unlike genomic analysis, provides a view of biological processes at their level of occurrence. The knowledge thus gained is important not only for a better understanding of renal physiology and pathophysiology, but also for the identification of disease markers and the development of new therapies. This review applies the science of proteomics to nephrology: our aim is to give an overview of the discipline, providing background information and outlining the scope, advantages and limitations of proteomics.

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Biomarkers Chromatography, Liquid Electrophoresis, Gel, Two-Dimensional Humans Kidney Diseases Mass Spectrometry Molecular Biology Nephrology Protein Array Analysis Proteome Proteomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Urine Journal Article Review

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Patricia J T A Groenen, Lambert P W J van den Heuvel. 2006-03-30. Teaching molecular genetics: Chapter 3--Proteomics in nephrology.. https://doi.org/10.1007/s00467-006-0064-z

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