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Two novel furan derivatives from Phellinus linteus with anti-complement activity.

Byung-Sun Min·Bong-Sik Yun·Hyeong-Kyu Lee·Hee-Jin Jung·Hyun-Ah Jung·Jae-Sue Choi
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Abstract

Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC50 values of 33.6 and 33.7 microM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.

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BasidiomycotaComplement ActivationComplement System ProteinsFuransHumansMagnetic Resonance SpectroscopyMolecular StructureJournal Article

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Byung-Sun Min, Bong-Sik Yun, Hyeong-Kyu Lee, Hee-Jin Jung, Hyun-Ah Jung, Jae-Sue Choi. 2006-04-11. Two novel furan derivatives from Phellinus linteus with anti-complement activity.. https://doi.org/10.1016/j.bmcl.2006.03.027

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