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A unique function for cyclin D3 in early B cell development.

A Byron Cooper·Catherine M Sawai·Ewa Sicinska·Sarah E Powers·Piotr Sicinski·Marcus R Clark·Iannis Aifantis
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Abstract

During hematopoiesis, stem cell proliferation is dependent on expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Here, analysis of Ccnd1(-/-), Ccnd2(-/-), Ccnd3(-/-) and Ccnd2(-/-)Ccnd3(-/-) mice showed that cyclin D3 was uniquely required for the development of pre-B cells. Transcription of Ccnd3 was dependent on expression of the common gamma-chain. In contrast, expression of the pre-B cell receptor and activation of 'downstream' signaling pathways prevented proteasome-mediated degradation of cyclin D3. Cyclin D3 has a key function in B cell development by integrating cytokine and pre-B cell receptor-dependent signals to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.

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AnimalsB-LymphocytesCell DifferentiationCell LineCyclin D3CyclinsMiceMice, KnockoutPolymerase Chain ReactionJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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A Byron Cooper, Catherine M Sawai, Ewa Sicinska, Sarah E Powers, Piotr Sicinski, Marcus R Clark, Iannis Aifantis. 2006-04-02. A unique function for cyclin D3 in early B cell development.. https://doi.org/10.1038/ni1324

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