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Endothelial function in HIV-infected persons.

Anthony Solages·Joseph A Vita·David J Thornton·Jessica Murray·Timothy Heeren·Donald E Craven·C Robert Horsburgh
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Abstract

BACKGROUND: Several reports have suggested an increased risk of coronary disease in human immunodeficiency virus (HIV)-infected patients receiving protease inhibitors (PIs). Impaired endothelium-dependent vasodilation is a putative surrogate marker of coronary atherosclerotic disease. METHODS: The present study evaluated the effect of HIV infection and antiretroviral treatment on endothelial vasomotor function, by assessing brachial artery flow-mediated dilation (FMD). A total of 75 HIV-infected patients were compared with 223 control subjects who were presumed to be HIV uninfected. RESULTS: HIV-infected patients had significantly impaired FMD, compared with control subjects (mean +/- SD, 7.3% +/- 4.4% vs. 11.1% +/- 6.3%; P < .0001). When adjustments were made for smoking status, sex, and body mass index, the difference between the 2 groups remained statistically significant (P < .01). In a cross-sectional analysis of the HIV-infected patients, we found significant associations between FMD and current injection drug use, hazardous drinking, HIV load, and alpha-high-density lipoprotein triglyceride levels, but not PI therapy. In a multivariate analysis, only current injection drug use and a lower alpha-high-density lipoprotein triglyceride level were significantly associated with FMD. CONCLUSIONS: HIV-infected patients have significant impairment of endothelial function, and this impairment is worse among those with elevated levels of HIV replication, particularly injection drug users.

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AdultCoronary Artery DiseaseEndothelium, VascularFemaleHIV InfectionsHumansMaleMiddle AgedRisk FactorsVasodilationJournal ArticleResearch Support, N.I.H., Extramural

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Anthony Solages, Joseph A Vita, David J Thornton, Jessica Murray, Timothy Heeren, Donald E Craven, C Robert Horsburgh. 2006-03-31. Endothelial function in HIV-infected persons.. https://doi.org/10.1086/503261

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