RNA targeting using peptide nucleic acid.

E Nielsen

doi:10.1007/3-540-27262-3_20

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RNA targeting using peptide nucleic acid.

E Nielsen

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Abstract

The efforts towards peptide nucleic acid (PNA) drug discovery using cellular RNAs as molecular targets is briefly reviewed, with special emphasis on recent developments. Special attention is given to cellular delivery in vivo bioavailability and the possibilities of using PNA oligomers to (re)direct alternative splicing of pre-messenger (m)RNA.

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Animals Biological Availability Drug Delivery Systems Humans Peptide Nucleic Acids RNA RNA Viruses RNA, Messenger Journal Article Review

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E Nielsen. 2006. RNA targeting using peptide nucleic acid.. https://doi.org/10.1007/3-540-27262-3_20

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