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PubMed · 16596483

TRX-4 (TolerRx Inc).

William M Brown
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Abstract

TolerRx Inc, under license from BTG plc, is developing TRX-4, an anti-CD3 humanized monoclonal antibody for the potential treatment of type 1 diabetes and psoriasis. Phase II trials of the therapeutic antibody in type 1 diabetes have been completed and the company is planning a pivotal phase III trial for this indication. TolerRx is also enrolling psoriasis patients in a phase Ib clinical study of TRX-4. TRX-4 has been awarded Orphan Drug status for recent-onset type 1 diabetes.

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Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedCD3 ComplexClinical Trials, Phase I as TopicClinical Trials, Phase II as TopicDiabetes Mellitus, Type 1Graft RejectionHumansKidney TransplantationPatents as TopicPsoriasisTreatment OutcomeJournal Article

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William M Brown. 2006. TRX-4 (TolerRx Inc).. https://pubmed.ncbi.nlm.nih.gov/16596483/

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