PubMed · 16597260
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R J Young. 2001. Futility--beyond a definition.. https://pubmed.ncbi.nlm.nih.gov/16597260/
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.