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PubMed · 16603103

Specific immunotherapy in atopic dermatitis.

Magdalena Czarnecka-Operacz·Wojciech Silny
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Abstract

Despite the existence of various scientific research on the beneficial effect of specific immunotherapy with specific airborne allergens in the treatment of atopic dermatitis, this method has not been easily accepted, as the methodology and the valuation of the studies were heterogeneous. Over the last few years, meta-analysis technology has been developed as a useful tool to globally value the results of different research trials related to one specific scientific problem. When meta-analyses are carried out correctly, they are accepted as the most appropriate way to express the results obtained from different studies. Not many studies have been published in the case of atopic dermatitis and specific immunotherapy. In this paper, we attempt to present and discuss results obtained by various authors on this topic, beginning with the publication of Strauss and Kligman in 1957. It should be noted that for patients with IgE-mediated airborne allergy, especially children, specific immunotherapy as an early treatment in cases of atopic dermatitis could have an additionally preventive nature in terms of protection against the development of a respiratory atopic problem. Specific immunotherapy should therefore be at least considered in the treatment of selected cases of atopic dermatitis patients presenting airborne IgE-mediated allergy.

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Dermatitis, AtopicDesensitization, ImmunologicHumansVaccinesJournal ArticleReview

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Magdalena Czarnecka-Operacz, Wojciech Silny. 2006. Specific immunotherapy in atopic dermatitis.. https://pubmed.ncbi.nlm.nih.gov/16603103/

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Single-cell transcriptome revealed the aberrant keratinocytes activation in antigen presentation in atopic dermatitis.

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PubMed2007

[Specific immunotherapy in the treatment of atopic dermatitis].

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that is part of the atopic syndrome and is frequently associated with asthma and allergic rhinoconjunctilitis. Acute eczematous lesions are characterized by erythema, cozing and crusting, whereas chronic lesions show thickened skin and papules. In addition to local and systemic therapy adjusted to the stage of the disease, the search for relevant trigger factors and consecutively their avoidance plays a crucial role in disease management. Aeroallergens like house-dust-mites, pollen and animal epithelia represent important trigger factors in sensitized patients. While allergen-specific immunotherapy (SIT) is widely and most effective used in allergy to insect venoms and allergic rhinitis, its use in AD is still controversial. Double-blind, placebo-controlled clinical trials show that SIT is effective in patients with AD and clinically relevant sensitization to house dust mites and grass pollen and leads to clinical improvement of eczema. Despite these encouraging data, the use of SIT as a routine therapeutic approach in AD requires further evaluation.

Dermatitis, Atopic↗