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A decrease in the immunoglobulin G antibody response against the VlsE protein of Borrelia burgdorferi sensu lato correlates with the resolution of clinical signs in antibiotic-treated patients with early Lyme disease.

Antonella Marangoni·Vittorio Sambri·Silvia Accardo·Francesca Cavrini·Valeria Mondardini·Alessandra Moroni·Elisa Storni·Roberto Cevenini
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Abstract

The purpose of this study was to evaluate the diagnostic performance of the LIAISON Borrelia Screen (Diasorin, Saluggia, Italy), a new automated immunoassay based on the chemiluminescent technology (chemiluminescence immunoassay). To assess whether a decrease in a negative value in the anti-VlsE immunoglobulin G (IgG) antibody titer was correlated with a positive response to treatment, a group of serially collected serum samples from 67 patients with culture-confirmed erythema migrans was retrospectively studied. All the patients had been treated with antibiotics and were free of disease within 3 to 6 months of follow-up. All the 15 patients who were found to be IgG positive at the time of enrollment and who were bled at least four times during the follow-up became IgG seronegative at 2 to 6 months posttreatment. These results indicate that a decline in the anti-VlsE antibody titer coincides with effective antimicrobial therapy in patients with early localized Lyme disease.

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AdultAgedAnti-Bacterial AgentsAntibodies, BacterialAntigens, BacterialBacterial ProteinsBorrelia burgdorferiFemaleHumansImmunoglobulin GImmunosuppression TherapyLipoproteinsLyme DiseaseMaleMiddle AgedRetrospective StudiesTime FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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Antonella Marangoni, Vittorio Sambri, Silvia Accardo, Francesca Cavrini, Valeria Mondardini, Alessandra Moroni, Elisa Storni, Roberto Cevenini. 2006. A decrease in the immunoglobulin G antibody response against the VlsE protein of Borrelia burgdorferi sensu lato correlates with the resolution of clinical signs in antibiotic-treated patients with early Lyme disease.. https://doi.org/10.1128/cvi.13.4.525-529.2006

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