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Solid-phase synthesis of CD40L mimetics.

Alberto Bianco·Sylvie Fournel·Sébastien Wieckowski·Johan Hoebeke·Gilles Guichard
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Abstract

The C3-symmetric molecule has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146 via a 6-aminohexanoic acid residue as a spacer. The present report describes a general solid-phase synthesis approach to and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated.

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ApoptosisCD40 LigandCell Line, TumorChromatography, High Pressure LiquidCombinatorial Chemistry TechniquesHumansMolecular MimicryMolecular StructureProtein BindingJournal ArticleResearch Support, Non-U.S. Gov't

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Alberto Bianco, Sylvie Fournel, Sébastien Wieckowski, Johan Hoebeke, Gilles Guichard. 2006-03-10. Solid-phase synthesis of CD40L mimetics.. https://doi.org/10.1039/b601528j

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