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Lung cancer development in primary smelter workers: a nested case-referent study.

Nils-Göran Lundström·Vagn Englyst·Lars Gerhardsson·Taiyi Jin·Gunnar Nordberg
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Abstract

OBJECTIVE: The objective of this study was to study the impact of work-related exposure to mainly arsenic and lead versus smoking in primary smelter workers developing lung cancer. METHODS: In a cohort of 3979 primary smelter workers, 46 subjects had contracted respiratory malignancies. They were compared with 141 age-matched male referents by conditional logistic regression analysis. RESULTS: Cases showed a significantly higher smoking rate as compared with referents: odds ratio (OR) = 4.0; 95% confidence interval (CI) = 1.6-10.1; P = 0.003. When restricted to smokers (33 cases, 63 referents), the cumulative air arsenic exposure index, but not the lead exposure indices, was significantly higher among the cases: OR = 1.07; 95% CI = 1.02-1.11; P = 0.005. CONCLUSIONS: Cumulative arsenic exposure and smoking were identified as risk factors for the development of lung cancer; lead exposure, however, was not.

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Arsenic PoisoningCase-Control StudiesCausalityCohort StudiesComorbidityFollow-Up StudiesHumansInhalation ExposureLead PoisoningLogistic ModelsLung NeoplasmsMaleMetallurgyModels, StatisticalOccupational DiseasesOccupational ExposureSmokingSurvival AnalysisSwedenComparative StudyJournal Article

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Nils-Göran Lundström, Vagn Englyst, Lars Gerhardsson, Taiyi Jin, Gunnar Nordberg. 2006. Lung cancer development in primary smelter workers: a nested case-referent study.. https://doi.org/10.1097/01.jom.0000201556.95982.95

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