The multifaceted mismatch-repair system.

Josef Jiricny

doi:10.1038/nrm1907

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The multifaceted mismatch-repair system.

Josef Jiricny

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Abstract

By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.

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Animals Base Pair Mismatch DNA Repair Drug Resistance Exonucleases Humans Models, Molecular Proliferating Cell Nuclear Antigen Journal Article Research Support, Non-U.S. Gov't Review

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Josef Jiricny. 2006. The multifaceted mismatch-repair system.. https://doi.org/10.1038/nrm1907

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