Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages.

A G Stewart; G Grigoriadis

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PubMed · 1662547

Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages.

A G Stewart·G Grigoriadis

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Abstract

Analogues of PAF were examined for their potency in stimulating either platelet aggregation or macrophage superoxide anion generation. Modification of either the alkyl side-chain or the acetyl side-chain increased the relative potency of PAF analogues in macrophages, but all these compounds were more active in platelets. However, an analogue of PAF with an increased inter-ionic distance in the polar head group, hexanolamine PAF, showed a greater potency in macrophages than platelets. The latter compound also appeared to act as a partial agonist in both rabbit platelets and guinea-pig macrophages, but not in guinea-pig platelets. Differences in the rank order of potency of the PAF analogues in stimulating these cell elements suggest that platelet and macrophage PAF receptors differ.

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Animals Blood Platelets Guinea Pigs Macrophage Activation Macrophages Male Platelet Activating Factor Platelet Aggregation Platelet Membrane Glycoproteins Rabbits Receptors, Cell Surface Receptors, G-Protein-Coupled Structure-Activity Relationship Superoxides Comparative Study Journal Article Research Support, Non-U.S. Gov't

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A G Stewart, G Grigoriadis. 1991. Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages.. https://pubmed.ncbi.nlm.nih.gov/1662547/

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