Altered cellular responsiveness during ageing.

S I Rattan; A Derventzi

doi:10.1002/bies.950131111

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Altered cellular responsiveness during ageing.

S I Rattan·A Derventzi

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Abstract

The capacity of cells and organisms to respond to external stimuli and to maintain stability in order to survive decreases progressively during ageing. The mitogenic and stimulatory effects of growth factors, hormones and other agents are reduced significantly during cellular ageing. The sensitivity of ageing cells to toxic agents including antibiotics, phorbol esters, radiations and heat shock increases. This failure of homeostasis during cellular ageing does not appear to be due to any quantitative and qualitative defects in the receptor systems. Instead, metabolic defects in the pathways of macromolecular synthesis may be the basis of altered cellular responsiveness during ageing.

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Aging Animals Anti-Bacterial Agents Cell Division Cellular Senescence DNA Damage DNA Repair DNA Replication Growth Substances Heat-Shock Proteins Humans Phorbol Esters Protein Biosynthesis Receptors, Cell Surface Journal Article Research Support, Non-U.S. Gov't Review

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S I Rattan, A Derventzi. 1991. Altered cellular responsiveness during ageing.. https://doi.org/10.1002/bies.950131111

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