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Influence of propolis water solution on heart mitochondrial function.

Daiva Majiene·Sonata Trumbeckaite·Arunas Savickas·Adolfas Toleikis
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Abstract

The effect of propolis water solution (PWS) on the respiration of rat heart mitochondria with NAD-linked (pyruvate + malate), FAD-linked (succinate) substrates and fatty acids (palmitoyl-L-carnitine) was investigated in this study. PWS at the lowest concentration of 4 microg mL(-1) of phenolic compounds (PC) had no effect on mitochondrial respiration with all investigated substrates. PWS at concentrations of 63 and 125 microg mL(-1) of PC caused a significant decrease of basal (24 and 54%) and maximal (58 and 70%) respiration rates with succinate as substrate. At these PWS concentrations the oxidation of pyruvate + malate and palmitoyl-L-carnitine was diminished to a lower degree: the basal respiration rate decreased by 13-18% and the maximal respiration rate by 15-28%. Succinate oxidation was affected, probably because of the inhibition of succinate dehydrogenase by the 1,2-benzenedicarboxylic acid esters found in PWS. The PWS-caused decrease in the mitochondrial respiration rate with pyruvate + malate and fatty acids could be due to diminished activities of respiratory chain complexes and/or ADP/ATP translocator.

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AnimalsDose-Response Relationship, DrugEnergy MetabolismIn Vitro TechniquesMalatesMaleMitochondria, HeartOxidation-ReductionPalmitoylcarnitinePropolisPyruvic AcidRatsRats, WistarSolutionsSuccinic AcidWaterComparative StudyJournal Article

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Daiva Majiene, Sonata Trumbeckaite, Arunas Savickas, Adolfas Toleikis. 2006. Influence of propolis water solution on heart mitochondrial function.. https://doi.org/10.1211/jpp.58.5.0017

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