Ligand binding by TPR domains.

Aitziber L Cortajarena; Lynne Regan

doi:10.1110/ps.062092506

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Ligand binding by TPR domains.

Aitziber L Cortajarena·Lynne Regan

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Abstract

Tetratricopeptide repeat (TPR) domains bind specific peptide ligands and are thought to mediate protein-protein interactions in a variety of biological systems. Here we compare peptide ligand-binding by several different TPR domains. We present specific examples that demonstrate that TPR domains typically undergo little or no structural rearrangement upon ligand binding. Our data suggest that, contrary to a recent proposal, coupled folding and binding is not the common mechanism of ligand recognition by TPR domains.

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Binding Sites Carrier Proteins Circular Dichroism Enzyme Stability Heat-Shock Proteins Ligands Magnetic Resonance Spectroscopy Models, Molecular Nuclear Proteins Peptides Phosphoprotein Phosphatases Protein Folding Protein Structure, Tertiary Structure-Activity Relationship Thermodynamics Journal Article Research Support, Non-U.S. Gov't

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Aitziber L Cortajarena, Lynne Regan. 2006. Ligand binding by TPR domains.. https://doi.org/10.1110/ps.062092506

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