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PubMed · 16641511

Processing body autoantibodies reconsidered.

Donald B Bloch·Tod Gulick·Kenneth D Bloch·Wei-Hong Yang
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Abstract

Processing bodies (P-bodies) are cellular structures that have critical roles in mRNA degradation and post-transcriptional gene silencing. Some patients with autoimmune disease have high titer antibodies directed against P-bodies, and certain sera have been used as markers for the GW182 component of these structures. This study shows that available reference sera are unreliable markers for GW182 because the sera contain antibodies directed against Ge-1, a second P-body autoantigen.

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Argonaute ProteinsAutoantibodiesAutoantigensAutoimmune DiseasesCarcinoma, HepatocellularCell Line, TumorEukaryotic Initiation Factor-2Fluorescent Antibody Technique, IndirectFluorescent DyesGreen Fluorescent ProteinsHumansImmunoblottingIndolesLiver NeoplasmsNuclear ProteinsPeptide Initiation FactorsProteinsRNA, MessengerRNA-Induced Silencing ComplexComparative StudyLetter

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Donald B Bloch, Tod Gulick, Kenneth D Bloch, Wei-Hong Yang. 2006. Processing body autoantibodies reconsidered.. https://doi.org/10.1261/rna.17406

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