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Variance component models for X-linked QTLs.

Kenneth Lange·Eric Sobel
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Abstract

This paper discusses the theory and implementation of a model for mapping X-linked quantitative trait loci (QTL). As a result of X inactivation, a female's body is subdivided into a number of patches. In each patch one of her two X chromosomes is randomly switched off. This smooths the allelic contributions in a heterozygote and implies that females should show less trait variation than males for an X-linked trait. The latest version of the genetic analysis program Mendel incorporates a simple variance component version of this model. An application to head circumference in autistic children illustrates Mendel in action.

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Analysis of VarianceFemaleGenes, X-LinkedGenetic Diseases, InbornGenetic VariationHumansModels, GeneticQuantitative Trait LociSoftwareX Chromosome InactivationJournal ArticleResearch Support, N.I.H., Extramural

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Kenneth Lange, Eric Sobel. 2006. Variance component models for X-linked QTLs.. https://doi.org/10.1002/gepi.20158

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