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PubMed · 16671782

Macrocycloadditions leading to conformationally restricted small molecules.

Ryan E Looper·Daniela Pizzirani·Stuart L Schreiber
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Abstract

[reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents.

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AlkynesAzidesCatalysisCopperCyclizationMacrocyclic CompoundsMolecular ConformationMolecular StructureStereoisomerismTriazolesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Ryan E Looper, Daniela Pizzirani, Stuart L Schreiber. 2006-05-11. Macrocycloadditions leading to conformationally restricted small molecules.. https://doi.org/10.1021/ol0604724

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