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Low-grade gliomas -- current concepts.

J Schramm·I Blümcke·C B Ostertag·U Schlegel·M Simon·J Lutterbach
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Abstract

Diffuse astrocytomas, oligodendrogliomas, and oligoastrocytomas (mixed gliomas) WHO grade II, pleomorphic xanthoastrocytomas (PXAs), pilocytic astrocytomas, and subependymal giant cell astrocytomas (SEGAs) are often referred to as low-grade gliomas. WHO grade II astrocytomas, oligodendrogliomas, and mixed gliomas are characterized by their infiltrative growth, frequent tumor recurrence and a more than 50 % risk for malignant progression. In contrast, pilocytic astrocytomas and SEGAs are circumscribed tumors amenable to a (radio)surgical cure. There are few universally accepted guidelines for the treatment of low-grade gliomas. In this review, three neurosurgeons, a neurologist, a neuropathologist, and a radiation oncologist discuss some of the difficult issues surrounding the diagnosis and treatment of low-grade gliomas from their individual points of view (i. e., classification and neuropathology, MR imaging, stereotactic biopsy, microsurgery, interstitial radiotherapy/brachytherapy, radiotherapy, wait and see strategy).

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Brain NeoplasmsCombined Modality TherapyGliomaHumansNeurosurgical ProceduresPrognosisSurvivalJournal ArticleReview

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J Schramm, I Blümcke, C B Ostertag, U Schlegel, M Simon, J Lutterbach. 2006. Low-grade gliomas -- current concepts.. https://doi.org/10.1055/s-2006-933408

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