Connexin43: emerging role in erectile function.

Georges Pointis

doi:10.1016/j.biocel.2006.03.007

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Connexin43: emerging role in erectile function.

Georges Pointis

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Abstract

Connexins, that have their main function as part of gap junction channels, are proteins expressed in a large number of tissues such as endocrine, nervous, vascular, and muscular tissues. Gap junctions are implicated in tissue homeostasis and control of cell proliferation and differentiation. Interestingly, mutations of connexin genes have been reported in several human diseases (peripheral neuropathies, cardiovascular and dermatological diseases, hereditary cataract, and deafness) and altered expression of connexins have been associated with tumoral progression. Today, several lines of study argue for a critical role of gap junctions in corporal smooth muscle relaxation and erectile response. The present review highlights the emerging role of connexin43, one of these membranous proteins, in the physiology and physiopathology of human erectile function and its possible medical application.

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Connexin 43 Erectile Dysfunction Gap Junctions Humans Male Penile Erection Protein Conformation Journal Article Research Support, Non-U.S. Gov't

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Georges Pointis. 2006-03-29. Connexin43: emerging role in erectile function.. https://doi.org/10.1016/j.biocel.2006.03.007

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