A time to divide: does the circadian clock control cell cycle?

Jacqueline A Walisser; Christopher A Bradfield

doi:10.1016/j.devcel.2006.04.014

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A time to divide: does the circadian clock control cell cycle?

Jacqueline A Walisser·Christopher A Bradfield

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Abstract

A variety of molecular, genomic and epidemiological evidence has linked cell cycle regulation to circadian rhythms. In a recent issue of Molecular Cell, Koeffler and colleagues show that PER1 sensitizes human cancer cells to ionizing radiation-induced apoptosis. In addition, PER1 expression was found to be downregulated in human tumors, suggesting a tumor suppressor role for the PER1 protein. The significance of PERs, clocks, and cell cycle control is discussed.

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Animals Cell Cycle Circadian Rhythm Gene Expression Regulation, Neoplastic Humans Mice Time Factors Journal Article

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Jacqueline A Walisser, Christopher A Bradfield. 2006. A time to divide: does the circadian clock control cell cycle?. https://doi.org/10.1016/j.devcel.2006.04.014

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