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PubMed · 16681834

Interferon signalling network in innate defence.

Akinori Takaoka·Hideyuki Yanai
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Abstract

Interferons (IFNs) elicit multifaceted effects in host innate defence. Accumulating evidence revealed that not only the first identified Jak-Stat pathway but also other newly found signalling pathways are required for the induction of versatile responses by IFNs. In particular, type I IFNs are inducible by viral infection through the recognition of pathogen-associated molecules by pattern recognition receptors, and the induction of multiple IFN-stimulated genes through the activation of type I IFN signalling confers antiviral and immunomodulatory activities. Any step in this process is often targeted by viruses for their immuno-evasion. The regulatory function of constitutive IFN-alpha/beta signalling has been recognized in terms of its boosting effect on cellular responsiveness in host defence systems. Further comprehensive understanding of IFN signalling may offer a better direction to unravelling the complex signalling networks in the host defence system, and may contribute to their more effective therapeutic applications.

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AnimalsGene Expression RegulationHepacivirusHumansImmunity, InnateInterferon Type IInterferon-alphaInterferon-betaInterferon-gammaParamyxoviridaeReceptors, InterferonSignal TransductionVaccinia virusVirus DiseasesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Akinori Takaoka, Hideyuki Yanai. 2006. Interferon signalling network in innate defence.. https://doi.org/10.1111/j.1462-5822.2006.00716.x

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