PubMed · 16701281
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Sean Nee. 2004. Professor John Maynard Smith 1920-2004.. https://doi.org/10.1016/j.tree.2004.05.007
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.