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PubMed · 16702983

First among equals: competition between genetically identical cells.

Anupama Khare·Gad Shaulsky
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Abstract

Competition between genetically identical organisms is considered insignificant in evolutionary theory because it is presumed to have little selective consequence. We argue that competition between genetically identical cells could improve the fitness of a multicellular organism by directing fitter cells to the germ line or by eliminating unfit cells, and that cell-competition mechanisms have been conserved in multicellular organisms. We propose that competition between genetically identical or highly similar units could have similar selective advantages at higher organizational levels, such as societies.

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AnimalsEukaryotic CellsEvolution, MolecularGenetic VariationHumansSelection, GeneticJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Review

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Anupama Khare, Gad Shaulsky. 2006-05-16. First among equals: competition between genetically identical cells.. https://doi.org/10.1038/nrg1875

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