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PubMed · 16720998

Peritoneal transport with icodextrin solution.

Olof Heimbürger
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Abstract

Icodextrin is the only large molecular weight osmotic agent available in peritoneal dialysis solutions. Icodextrin (compared to glucose) has a prolonged positive ultrafiltration because of the slow absortion of icodextrin due to its large molecular weight. As icodextrin induces transcapillary ultrafiltration by a mechanism resembling 'colloid' osmosis (with the ultrafiltration occurring mainly through the small pores) almost no sieving of solutes is observed with icodextrin-based solution resulting in increased convective transport and clearance of small solutes. In general, the transport characteristics of the peritoneal membrane are similar with glucose- and icodextrin-based solution, but results from the EAPOS study suggests that use of icodextrin-based solution may be associated with less changes in peritoneal transport with time.

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Biological TransportDialysis SolutionsGlucansGlucoseHumansIcodextrinPeritoneal DialysisPeritoneumUltrafiltrationJournal ArticleReview

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BibTeXRIS

Olof Heimbürger. 2006. Peritoneal transport with icodextrin solution.. https://doi.org/10.1159/000093508

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