The relationship between mitochondrial shape and function and the cytoskeleton.

Vasiliki Anesti; Luca Scorrano

doi:10.1016/j.bbabio.2006.04.013

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PubMed · 16729962

The relationship between mitochondrial shape and function and the cytoskeleton.

Vasiliki Anesti·Luca Scorrano

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Abstract

Mitochondria are crucial organelles for life and death of the cell. They are prominent players in energy conversion and integrated signaling pathways including regulation of Ca2+ signals and apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport at specialized cellular sites. This transport occurs by interactions with a variety of cytoskeletal proteins that also have the ability to influence shape and function of the organelle. A growing body of evidence suggests that mitochondria use cytoskeletal proteins as tracks for their movement; in turn, mitochondrial morphology and function is regulated via mostly uncharacterized pathways, by the cytoskeleton.

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Vasiliki Anesti, Luca Scorrano. 2006-04-19. The relationship between mitochondrial shape and function and the cytoskeleton.. https://doi.org/10.1016/j.bbabio.2006.04.013

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