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PTPN22: setting thresholds for autoimmunity.

Peter K Gregersen·Hye-Soon Lee·Franak Batliwalla·Ann B Begovich
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Abstract

The 620W allelic variant of the intracellular tyrosine phosphatase, PTPN22, is associated with a number of different autoimmune disorders, and this provides direct evidence for common mechanisms underlying many of these diseases. The associated allele appears to influence thresholds for T cell receptor signaling, and a variety of disease models involving both central and peripheral tolerance can be proposed. However, given the fact that PTPN22 is expressed in a variety of immunologically relevant cell types, the precise mechanisms for these associations remain unclear. In general, the PTPN22 620W allele appears to play a role in autoimmune disorders that have a prominent humoral component, suggesting that further investigation of PTPN22 activity in B cells will be useful. From a genetic perspective, the data highlights the genetic heterogeneity underlying autoimmunity in different ethnic groups.

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AllelesAnimalsAutoimmune DiseasesGenetic VariationHumansProtein Tyrosine Phosphatase, Non-Receptor Type 22Protein Tyrosine PhosphatasesReceptors, Antigen, T-CellSignal TransductionT-LymphocytesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReview

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Peter K Gregersen, Hye-Soon Lee, Franak Batliwalla, Ann B Begovich. 2006-05-30. PTPN22: setting thresholds for autoimmunity.. https://doi.org/10.1016/j.smim.2006.03.009

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