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PubMed · 16735595

Kinin receptor expression during Staphylococcus aureus infection.

Sara H Bengtson·Stephen B Phagoo·Anna Norrby-Teglund·Lisa Påhlman·Matthias Mörgelin·Bruce L Zuraw·L M Fredrik Leeb-Lundberg·Heiko Herwald
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Abstract

An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg(9)bradykinin. The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections.

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Antigens, BacterialBase SequenceCell LineCytokinesDNAHumansMicroscopy, ImmunoelectronModels, BiologicalMonocytesRNA, MessengerReceptor, Bradykinin B1Receptor, Bradykinin B2Staphylococcal InfectionsStaphylococcus aureusSuperantigensJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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Sara H Bengtson, Stephen B Phagoo, Anna Norrby-Teglund, Lisa Påhlman, Matthias Mörgelin, Bruce L Zuraw, L M Fredrik Leeb-Lundberg, Heiko Herwald. 2006-05-30. Kinin receptor expression during Staphylococcus aureus infection.. https://doi.org/10.1182/blood-2006-04-016444

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