Staying in shape with formins.

Jan Faix; Robert Grosse

doi:10.1016/j.devcel.2006.05.001

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Staying in shape with formins.

Jan Faix·Robert Grosse

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Abstract

Formins constitute a diverse protein family present in all eukaryotes examined. They are defined by the presence of a formin homology 2 (FH2) domain, which possesses intrinsic and conserved functions regulating cytoskeletal dynamics. Over the past few years, formins have become recognized as potent nucleators of linear actin filaments that control a large variety of cellular and morphogenetic functions. Here, we review the molecular principles of formin-induced cytoskeletal rearrangements and their consequences for a growing number of biological processes.

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Actin Cytoskeleton Animals Contractile Proteins Humans Microfilament Proteins Models, Biological Protein Binding Protein Structure, Tertiary Journal Article Research Support, Non-U.S. Gov't Review

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Jan Faix, Robert Grosse. 2006. Staying in shape with formins.. https://doi.org/10.1016/j.devcel.2006.05.001

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