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PubMed · 16750003

[Introduction on "case-sibling control design"].

Hong-gang Yi·Feng Chen·Hao Yu·Yang Zhao·Dong-hua Lou
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Abstract

OBJECTIVE: To introduce the design and statistical methods of case-sibling control design and to analyze the published data. METHODS: Data from an association study between the coronary heart disease and methylenetetrahydrofolate reductase gene C677T polymorphism was analyzed by the sib transmission/disequibrium test (s-TDT) and the sibship disequilibrium (SDT) methods. RESULTS: Using s-TDT method, Z value was 0.27 with P > 0.05. The result of SDT method showed that chi-square was 0.31 with 1 df, P > 0.05. All results suggested that neither s-TDT nor SDT showed significant difference between the transmitted and untransmitted methylenetetrahydrofolate reductase gene C677T allele distributions. CONCLUSION: Case-sibling control design might avoid population stratification by using siblings as controls thus might be used to test association and linkage between genes and disease.

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Case-Control StudiesChi-Square DistributionCoronary DiseaseEpidemiologic MethodsGene FrequencyGenetic Association StudiesGenetic LinkageHumansMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, GeneticResearch DesignSiblingsEnglish AbstractJournal Article

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Hong-gang Yi, Feng Chen, Hao Yu, Yang Zhao, Dong-hua Lou. 2006. [Introduction on "case-sibling control design"].. https://pubmed.ncbi.nlm.nih.gov/16750003/

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