Quality control in self/nonself discrimination.

Thomas Boehm

doi:10.1016/j.cell.2006.05.017

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Quality control in self/nonself discrimination.

Thomas Boehm

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Abstract

Unicellular eukaryotes primarily employ self/nonself discrimination to avoid self-mating, whereas multicellular organisms also use self/nonself discrimination in immune defense. Recent advances in understanding self/nonself discrimination in eukaryotes shed new light on the emergence of the most sophisticated self/nonself discrimination system known, the antigen receptors employed in the adaptive immune system.

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Animals Eukaryotic Cells Evolution, Molecular Fungi Humans Immunity, Innate Immunologic Surveillance Killer Cells, Natural Peptides Plants Receptors, Antigen Reproduction Journal Article Research Support, Non-U.S. Gov't Review

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Thomas Boehm. 2006-06-02. Quality control in self/nonself discrimination.. https://doi.org/10.1016/j.cell.2006.05.017

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