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PubMed · 16754543

Attention-deficit/hyperactivity disorder: a plausible mouse model?

Sylvie Granon·Jean-Pierre Changeux
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Abstract

UNLABELLED: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial and heterogeneous disorder, highly prevalent in children and characterized by three main components: inattention, lack of inhibitory control and hyperactivity. Epidemiological evidence reveals that ADHD is associated with nicotine exposure, mostly, with prenatal cigarette smoking. Mice deleted for the beta2-subunit gene of the neuronal nicotinic receptor are proposed as a simple and reliable animal model for ADHD. CONCLUSION: Nicotinic agonists targeting the alpha4beta2 nicotinic receptors alleviate ADHD symptoms and may possibly contribute to an efficient therapy of ADHD children.

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Sylvie Granon, Jean-Pierre Changeux. 2006. Attention-deficit/hyperactivity disorder: a plausible mouse model?. https://doi.org/10.1080/08035250600719747

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