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PubMed · 16759083

Multivalent antimicrobial peptides from a reactive polymer scaffold.

Zhigang Liu·Heather Deshazer·Amanda J Rice·Kang Chen·Chunhui Zhou·Neville R Kallenbach
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Abstract

We report an application of the principle of multivalency to create new antimicrobial agents using the reactive polymaleic anhydride (PMA) chain to link antimicrobial tetrapeptides to afford multivalent variants containing approximately 40 monomer units. Relative to the free peptides, the product shows a 10-fold improvement in IC(50) without provoking more severe hemolysis of red blood cells. Thus, multivalency or polyvalency may offer a route to enhance the activity of antimicrobial peptides.

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Anti-Infective AgentsBacillus subtilisDrug DesignEscherichia coliMagnetic Resonance SpectroscopyMaleic AnhydridesMicrobial Sensitivity TestsOligopeptidesPolymersJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.

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Zhigang Liu, Heather Deshazer, Amanda J Rice, Kang Chen, Chunhui Zhou, Neville R Kallenbach. 2006-06-15. Multivalent antimicrobial peptides from a reactive polymer scaffold.. https://doi.org/10.1021/jm0601452

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