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Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.

Xuesen Fan·Xinying Zhang·Longhu Zhou·Kathy A Keith·Earl R Kern·Paul F Torrence
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Abstract

The nucleoside 5-formyl-2'-deoxyuridine has been used as a starting point for the generation of novel 5-substituted pyrimidine nucleosides that are shown to possess significant antiviral activity against two representative orthopoxviruses, namely vaccinia virus and cowpox virus.

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AnimalsBiological WarfareCowpox virusHumansMicrobial Sensitivity TestsPyrimidine NucleosidesSmallpoxVaccinia virusJournal Article

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Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A Keith, Earl R Kern, Paul F Torrence. 2006-05-19. Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.. https://doi.org/10.1016/j.antiviral.2006.04.015

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